AST ( aspartate aminotransferase ) : norm and deviation

AST (aspartate aminotransferase) catalyzes the transfer of amino groups in the alpha-ketoglutaric acid from aspartic greater amount of it is found in liver, bones, heart and kidneys, and it is contained in the pancreas and lung.It is composed of cytoplasmic and mitochondrial isoenzymes species.Normal AST when only cytoplasmic isoenzymes in the blood serum.

What is the ACT?What is its value?

AST is the main indicator in the defeat of the cells in the heart muscle and liver cells.It is used in viral, toxic liver disease, myocardial infarction, and preventive examinations.

AST is an enzyme that participates in the metabolism of amino acids into cells.It is a part of erythrocytes, skeletal muscle, heart and liver.In case of damage to the cells, the enzyme can be rapidly detected in CROI.In cases of acute and chronic nature, which are accompanied by the destruction of the cells, an enzyme in the blood begins to fall.He was particularly active in myocardial infarction.Its activity can be registered as ear

ly as 6 hours after a heart attack appeared, then after 24 hours and after 72 hours there hyperenzymemia.

normalize activity can only 7 per day.Also of AST can increase in hepatitis, liver diseases of different nature.After raising the normalized result can be only 35 days.Reduced AST in cases of hepatic necrosis in viral hepatitis.Remember, if hepatitis is an acute form, ALT is higher than AST.In cases of liver cirrhosis AST greater than ALT.

In cases of myocardial infarction, AST in the blood rises by 20 times, and the high activity is detected even before the first symptoms appeared, and they can be seen on an electrocardiogram.

There is a relationship between the foci of necrosis, which are located in the heart muscle and ACT indicators that will melt after a famous study of blood serum.In cases when on the third day figure AST is not reduced, the forecasts for the patient is very poor.

Watching begins to increase as the level of AST in the blood, we can draw conclusions about how expanding infarction lesions, whether the given process at the tissue of other organs, particularly the liver.In cases of myocardial infarction AST indicators may not climb much while using indicator de Rytis can learn about the difference between AST and ALT, ALT while greatly increasing.

How to determine the level of aspartate aminotransferase?

To determine AST uses a special UV kinetic test that meets the modern standards.In men, the norm - AST is up to 37 IU / L for women up to 31 IU / L.

material for tests on blood serum AST, 1 ml is sufficient.It must be stored at a temperature of 15 -25 degrees is not more than two days.In cases when the temperature of 2-8 degrees, no longer possible to store than seven days.At 20 degrees, can store more than one week.

blood is collected in a special vacuum system that has no anticoagulant but contained in vacuo to clot activator.When the material already assembled, it immediately for two hours at a temperature of 2-8 degrees is delivered to the laboratory.
Note that in modern medicine to determine the activity of AST in myocardial infarction, is not recommended to use the biomarker.There are special techniques such as determining the level of troponin and CK-type.

How to prepare for the analysis on the ACT?

Home for tests on an empty stomach, preferably in the morning.The patient needs to know that with this study can check the functioning of the heart and liver.Be sure to pre-warn patients that the study will need to pass three times the blood, first, when the patient is only done then in the next two days.

patient should know that they can cause discomfort when a tourniquet and puncture the vein.You do not need to follow a special study of diet and nutrition.You should also inform your doctor about medicines you are taking, or have taken, they have a very strong influence on the result.

What factors influence the test results?

increases the level of ACT drugs and medicines that contain cholestasis.Because it is so important to give them a few more days before delivery of the analysis.

Due thereby increasing the level of AST?

In cases of overstatement AST, your doctor may suspect an acute form of hepatitis.In cases of moderate increase, it can be argued that the damaged hepatocytes diverse etiology or a person myocardial necrosis, or necrosis of the muscles of the skeleton.

increase may also be due to inflammatory diseases which are associated with heart or muscles due to thermal shock, severe burns, hypothyroidism, bowel obstruction, i.e. increase AST may indicate necrosis in the intestinal wall.

Treatment AST deviation from the norm

increases the level of AST may be due to a variety of diseases or medications, which include a variety of chemicals.Therefore, in cases of deviation from the norm, it is necessary to consult a highly qualified specialist, who will examine your illness completely, draw conclusions, what happens to your body, which diseases you are predisposed, can you already have some kind of virus or chronic illnesses.Only on the basis of these analyzes the doctor prescribes a course of treatment for specific diseases.

So, it is important to monitor the level of AST in the blood, a deviation from the norm may indicate that such serious diseases - acute or chronic liver disease, toxic injury, myocardial infarction, thrombosis, pulmonary embolism, alcohol intoxication, alcoholic hepatitis, fleeting viral hepatitis, severe heartfailure, cancer, liver cirrhosis, infectious mononucleosis, an injury, muscular dystrophy, dermatomyositis, acute pancreatitis, kidney disease and pregnancy.