Therapeutic valproic acid - Normotimiki, Protivoelilepticheskie funds.Names of drugs - sodium valproate, calcium valproate, Apilepsin, Atsediprol, valparin XP, Depakine, Depakine enteric 300 Dipromal, Konvuleks, Konvulsofin, Orphir, Enkorat.
valproic acid - instructions for use
Doses and frequency of the use of valproic acid For adults the daily dose at the start of treatment is 0.3-0.6 g, for 1 -2 weeks it gradually increased to 0, 9-1,5 g, single dose for adults, for children 0.3-0.45 g-daily dose of 15-50 mg / kg (at the beginning of 15 mg / kg, and then gradually increased to 10.5 mg /kg per week).
beginning of Valproic acid acts A few hours
duration of action of valproic acid Maximum efficiency: 12 hours or more;then the efficiency is gradually reduced.
If valproic acid is omitted Take the missed dose as soon as you remember about it.If it is not long before the time for your next dose, skip the previous and return to the normal regimen.Do not double the next dose without c
discontinuation of valproic acid abrupt discontinuation can lead to seizures.If necessary, discontinuation of the drug the doctor within a few weeks gradually reduce the dose.
valproic acid - specific instructions Take during or immediately after a meal to reduce the risk of stomach irritation.Syrup can be taken with fluids, but avoid fizzy drinks.Do not change the brand name of the drug without consulting your doctor.
Indications for use of valproic acid
Various forms of generalized seizures in epilepsy;focal seizures and children tick.
Medicinal properties of valproic acid
Increases of GABA in the nervous system, thereby reducing the level of the threshold of excitability and seizure.
Side effects of valproic acid and contraindications
Contraindications for use of valproic acid Hypersensitivity, including "family" (death of close relatives in patients receiving valproic acid), diseases of the liver and pancreas (in some patients maysignificant reduction in metabolism in the liver), hemorrhagic diathesis, pregnancy (I term), breast-feeding.
Restrictions on the use of valproic acid Children's age (simultaneous appointment of several anticonvulsants), bone marrow aplasia.In the later stages of pregnancy application is possible if the expected benefit outweighs the potential risk.
The side effects of valproic acid severe abdominal pain and vomiting, muscle weakness and lethargy, yellow staining of the skin or eyes, swelling of the face, abnormal bleeding or bruising, or cramps can be signs of liver failure and other life-threatening complications.Seek immediate medical attention.There may be nausea and vomiting, heartburn, diarrhea, cramps, loss of appetite and weight loss, or increased appetite and weight gain, hair loss, tremor, dizziness, confusion, clumsiness or unsteadiness, drowsiness.Rare manifestations of anxiety, constipation, unusual irritability, skin rash, headache, vague or double vision, irritability, or other changes in mental status.Side effects are very diverse and very individual.Talk to your doctor if you are concerned about any unusual reaction.
valproic acid issuance
- drops for oral administration
- powder lyophilized for injection
Precautions for the use of valproic acid
Older than 60 years elderly patients require dose reduction to reduce the severity of side effects.
Driving the car and work with mechanisms drug can cause drowsiness or dizziness.Avoid these activities until they find out how the medicine affects you
Alcohol may increase drowsiness and increase the risk of liver damage.
overdose of valproic acid anxiety, drowsiness, hallucinations, hand tremors, loss of consciousness.Immediately call a doctor, emergency room or contact the nearest poison control center.
Interactions Enhances the effect of other anticonvulsants, sedatives and hypnotics.Aspirin and other nonsteroidal anti-inflammatory drugs, heparin, warfarin while taking valproic acid increases the risk of bleeding.Isoniazid and other hepatotoxic substances increase hepatotoxicity.Antispasmodic and enveloping means reduce the likelihood of diarrheal disorders.Interaction with food was observed.