drug Trental belongs to the vasodilating drugs.It is well improves blood circulation by the smallest capillaries, is angioprotectors and xanthine derivatives.
Trental - instructions for use in a variety of dosage forms
Instructions for Use Trental as tablets
Each tablet in its composition has the active substance:
- Pentoxifylline 100mg.
Excipients: lactose, starch, talc, colloidal silicon dioxide, magnesium stearate.The composition
shell include: methacrylic acid copolymer, sodium hydroxide, macrogol 800, talc, titanium dioxide.
Take tablets should not chewed, wholly and drink plenty of fluids.Eat them should either during or immediately after a meal.The purpose of the dosage and duration of treatment has been a doctor.The usual dose is 1 tablet three times a day, the dose is gradually increased to two tablets 2-3 times daily.
At night you can take a maximum of not more than 1200 mg Trental.Patients who suffer from renal disease, may take only daily 1-2 tablets.Patients who have low blood
Instructions for use Trental in the form of injections
Concentrate for solution for injection contains the same active ingredient - pentoxifylline.One vial contains 20 mg of it.As auxiliary substances are used, sodium chloride and water for injection.The drug is administered intravenously.The dosage prescribed by the physician taking into account the condition of the patient and the severity of circulatory disorders.Most often, the patient is prescribed two injections of 3.2 ampoules which is dissolved in 250 ml or 500 ml of a 9% sodium chloride solution.
Pentoxifylline injected necessarily slow, 100 mg per hour.Given comorbidities dosage may be decreased by the attending physician.After the morning injection can be assigned to receive tablet formulation of Trental.If possible, only one infusion per day, then appoint an additional 2 tablets Trental day and one night.In
day should be administered more than 1200 mg of active ingredient, can generally be calculated based on 0.6 mg per kilogram body weight per hour.For example, for a patient weighing 70 kg the daily dose will sostavlyat1000 mg of pentoxifylline.During treatment, the dosage may be reduced in patients with diseased liver.
Special instructions for use Trental
If the doctor prescribes Trental to patients who suffer from low blood pressure, the therapy should be carried out under the strict control of blood pressure.Diabetics who take hypoglycemic agents, should monitor blood sugar levels as well as the reception Trental may cause hypoglycemia, the dosage must be adjusted.
If the patient is taking anticoagulants, it is necessary to control the clotting of blood.After the surgery will have to take into account and carefully monitor the level of hemoglobin.For patients in advanced age, the dosage should be individualized with regard to their general condition and comorbidities.
Reception pentoxifylline in children is undesirable, as there is no reliable data on the safety of the drug in this age.If the patient is abusing smoking, the effectiveness of treatment Trentalom may significantly decrease.It is also necessary to take into account, especially if the treatment is carried out at home, injections should be done in a prone position.
storage conditions of the drug Trental
Store Trental must be away from sunlight and children, and at a temperature of 8 to 25 degrees above zero.
Indications, contraindications, side effects of Trental
Indications for use Trental Trental
has a wide range of applications.Indications for his appointment are:
- Problems with peripheral circulation.
- diabetic angiopathy.
- trophic ulcers.
- consequences of atherosclerosis in the form of impaired attention, memory.
- Coronary heart disease.
- condition after stroke.
- Post-thrombotic syndrome.
- blood circulation in the organ of vision.
- Pathological changes in hearing.
Under these conditions the drug can be administered as a tablet and by injection.Purpose does the doctor after a full examination of the patient.
Trental proved effective in the following diseases:
- Raynaud's disease.
- Impotence caused by circulatory problems.
- Coronary heart disease.
- Discirculatory encephalopathy.
Contraindications for use Trental
Contraindications in the preparation are also available, before use should be read with them.If appointed Trental in the form of tablets, their intake is not recommended for:
- Hypersensitivity to pentoxifylline.
- extensive bleeding.
- hemorrhage in the eye.
- myocardial infarction.
- brain hemorrhage.
- during pregnancy.
- During the period of breastfeeding.
Particular caution while taking Trental should be observed if:
- There is a cardiac arrhythmia.
- patient suffers from low blood pressure.There
- heart failure.
- There gastric ulcer and 12 duodenal ulcer.
- Diagnosed kidney disease.
- recently had surgery.
- Increased risk of bleeding with excessive bleeding.
To receive Trental injection, except for contraindications listed for tablets, has its contraindications:
- coronary and cerebral artery atherosclerotic plaque.
- Children up to 18 years.
Side effects when using Trental
no matter how safe the drug was, there is always the risk of side effects.After receiving Trental often following undesirable effects are observed:
From the nervous system: headaches, constant anxiety, sleep disturbances, convulsions may occur.
For the skin: redness of the skin, blood flow to the breast department, the appearance of edema, become brittle nails.
part of the intestine: anorexia, atony bowel.
On the part of the heart and blood vessels: tachycardia or fibrillation, rapid strokes, lowering blood pressure.
From the side of hematopoiesis: vascular bleeding, leukopenia, thrombocytopenia.
observed problems with the senses, such as reduced visual acuity.Possible allergic reactions to the drug in the form of urticaria, pruritus, in severe cases, anaphylactic shock.Suffice it rarely develops aseptic meningitis.If appointed Trental pills, perhaps a feeling of heaviness in the stomach, feeling its overcrowding, nausea and vomiting.
overdose when using Trental
If side effects are relatively rare, overdose is possible, if you do not comply with the treatment regimen prescribed by the doctor.It has the following symptoms:
- After receiving an overdose of tablets may be: nausea, vomiting, loss of pressure, redness of skin, tachycardia, convulsions and loss of consciousness.
- After overdose possible solution for infusion: general weakness, dizziness, nausea, tachycardia, drowsiness, or vice versa excitation, gastrointestinal bleeding, seizures and loss of consciousness.
treatment when it should be limited to receiving drugs that eliminate the symptoms.First of all, it is necessary to monitor blood pressure and respiratory function.In the presence of seizures can be given Diazepam.Once seen signs of overdose, the drug should be stopped immediately.
Application Trental in pregnancy
Advanced Studies about the effects of Trental in pregnant women have been conducted.Petoksifillin and its metabolites enter the breast milk.Therefore, if necessary, treatment during breastfeeding the baby will have to transfer to artificial feeding.
Trental Trental After receiving the blood improves its flow, as the active ingredients of the drug affect the deformability of red blood cells modified, reduced platelet aggregation.Trental improves blood circulation in the areas of its violation.Trental main component is pentoxifylline, which inhibits phosphodiesterase and cAMP accumulation in cells of the smooth muscle of blood vessels and blood elements.
Therapy Trentalom ends ameliorating the cerebral circulation.In the treatment of intermittent claudication distance becomes longer walk, nightly cramps.Pentoxifylline is almost completely adsorbed in the digestive tract.Eliminated via the kidneys in the form of water-soluble metabolites.
Trental interaction with other drugs
Trental Simultaneous treatment with drugs to lower blood pressure, enhances the action of the latter.Pentoxifylline increases the effects of anticoagulants, thrombolytics and antibiotics.If appointed by the concomitant use of Trental and cimetidine, the increased risk of side effects.Xanthines may cause increased tension.
Trental may increase the effects of insulin, so you need a special control of the blood parameters in patients with diabetes.
Analogs Trental: domestic and foreign
practically isolated cases when the drug does not have any counterpart on the active substance.Trental is such a decent amount, among them the most known the following:
Before you buy at the pharmacy instead of Trental its equivalent, it is necessary to consult a physician, if the same therapeutic effect you'll get from the treatment.
Comparative characteristics Trental with others
All analogs are composed of the same active ingredient as the original, but you can find the difference in its amount, bioavailability, shown excretion.For example, Agapurin often appointed when there are problems in the blood circulation in the limbs, for the treatment of bronchial asthma, nephritis.Bioavailability agapurin slightly smaller than Trental, and is about 90%.The same can be said about the launch period - it exceeds that of Trental by half an hour.
Pentoxifylline is used in coronary heart disease, Raynaud's disease.Bioavailability is also inferior Trentalu.It is noteworthy that significantly more Pentoxifylline has side effects.To those that occurred in Trental can still add, hallucinations, tremors, limb, meningitis, dry mouth, thirst, pain in the ears, changes in taste, constant nasal congestion.
flowerpots well improves blood circulation in the extremities, the central nervous system, kidneys.Pot has a maximum bioavailability of any analogues and compared to Trentalom.This is ideal for enhanced treatment as in one tablet contains 600 mg of active substance.
If we compare with the rest of Latro peers, he has a wide range of activities the most.Summarizing, we can say that any analogue at a price cheaper than Trental and therapeutic effect is almost the same.In addition, bioavailability and all about the same, except Vazonita.
reviews about the drug Trental
addressed to the hearing care professional about the constant noise in the ears, dizziness.Trental doctor prescribed tablets of 400 mg three times a day.Despite the fact that I suffer from low blood pressure, but during treatment with big jumps were observed, but the symptoms began to wane pretty quickly.Since then, I often turn to the drug help.
long suffered hearing loss, but Trental prescribed me only recently.The drug I am happy, not only hearing improved, but a better state of health considerably.One feels that the cells and tissues are better supplied with blood.Now I will drink it periodically courses 2 times a year.