Chronic myelogenous leukemia - Treatment and stage

Chronic myelogenous leukemia - the disease of tumor nature, arising from progenitor cells myelopoiesis, differentiated by stages of chronic myeloid leukemia to mature forms.Over time, through the process of metastatic spread to lymph nodes, liver, spleen, skin, other organs and tissues in later stages of chronic myeloid leukemia.These tumor cells have mieloleykoznye "Philadelphia" chromosome - chromosome anomaly with short long arms in the 22th pair.Treatment of chronic myeloid leukemia at different stages - different.

Treatment of chronic myeloid leukemia

What is needed for the treatment of chronic myeloid leukemia?

Treatment is determined by the stage of disease and usually begins with the progression of leukemic process.Prior to this, patients mielooeykozom various stages recommended for the treatment of high-grade fortified food, the observance of work and rest, periodic monitoring in the doctor-hematologist.In advanced stages of the main treatment is mielosan myeloid 2 - 6 mg per day, then wh

en the number of leukocytes in peripheral blood of 7 - 20 x 109 / L to supportive therapy - 2 - 4 mg mielosana a week for treatment.With the ineffectiveness of the treatment of chronic myeloid leukemia mielosanom appoint mielobromol - 0.25 1 g once a day, course dose - 2 - 6, the

If the primary clinical sign of chronic myeloid leukemia early stages is splenomegaly, not white blood cells is below 100 x 109 liters, can beappoint radiotherapy.radiotherapy treatment is stopped while reducing the number of leukocytes to 7 - 20 x 109 / L.Under blast crisis in chronic myeloid leukemia prescribed treatment regimen used in acute myeloid leukemia: VAMP, and Cytosar rubomycin, Vincristine and Prednisolone.The development of anemia, thrombocytopenic hemorrhage and infection is an indication for transfusion of red cells, platelet and antimicrobial therapy.

stages of chronic myeloid leukemia

What are the stages of chronic myelogenous leukemia?

disease naturally goes through several stages of development: 1) chronic, 2) progressive and 3) blast crisis.In the early stages of chronic phase chronic myeloid leukemia patients feel good, rarely Noting general weakness, fatigue.Several enlarged liver and spleen size.Most often the first symptom of chronic myeloid leukemia in the early stages is leukocytosis with a shift to myelocytes and promyelocytes.

After 2 - 10 years or more develops progressive stage of chronic myeloid leukemia, which may last 2 - 5 years and is characterized by a deterioration of general condition, a significant increase of the number of leukocytes, mainly due to myelocytes and promyelocytes, hepatomegaly and splenomegaly, ossalgia, anemia,thrombocytopenia, and enlarged lymph nodes. In this step, spleen and heart attacks occur episplenitis.

Further unpredictable stage of development (often in the background of cytostatic therapy and moderate pathological changes in the blood) disease becomes overbearing stage crisis.Progressing cachexia at this stage, rapidly increasing the liver and spleen, heart attacks occur in them;fever gets high and stable, there are pains in the bones, develops dense pockets sarkomnogo growth in the skin, lymph nodes (mielosarkoma).Accordingly, it is changing the blood picture and bone marrow at this stage of the treatment of chronic myeloid leukemia.The hemogram and myelogram revealed a significant number of myeloblasts: in the peripheral blood of more than 20% - blast crisis, in myelogram - from 25 to 95%.Monoklonovaya population at this stage of chronic myeloid leukemia tumor cells with "Philadelphia" chromosome is replaced polyclonal differing sharply anaplasia cells (deformity and increase the diameter of the cells, etc..).

The severity of chronic myeloid leukemia compounded by acceding bacterial infections, hemorrhagic diathesis, portal vein thrombosis, heart attacks the liver and spleen, leukemic infiltration of large nerve trunks with paresis and paralysis.The main causes of death in patients with chronic myeloid leukemia - a general intoxication, pneumonia, hemorrhagic syndrome, at least - necrotic processes.