Addison's Disease |Cushing's Syndrome

Addison's disease

Addison's disease develops as a result of functional adrenal insufficiency, when there is excess secretion of adrenocorticotropic hormone of the adrenal cortex and melanocyte stimulating hormone (a hormone that causes the pigment melanin).

symptoms of Addison's disease

most typical external symptom of Addison's disease is increased skin pigmentation.The pigment melanin is primarily deposited in the hard areas of maximum skin friction in areas that are exposed to sunlight.In addition, sometimes the increased melanin deposits are the nipples of mammary glands and mucous membranes (lips, cheeks, etc.).With further development of the disease becomes generalized hyperpigmentation.

Sometimes some of the patients against the overall increased skin pigmentation occur non-pigmented areas - vitiligo, which is an indicator of the patient's autoimmune process.Women who suffer from chronic insufficiency of the adrenal cortex, hair loss occurs in Addison's disease, which is associated with t

he production of male hormones in the adrenal glands, which are synthesized predominantly in men in the testes.

Syndrome Cushing's

Syndrome Cushing's develops when excessive content in the body of glucocorticoids (adrenal hormones), which can be caused by a lesion of the pituitary gland, the hypothalamus and the adrenal glands themselves, as well as long-term treatment with hormones (prednisolone, dexamethasone, etc..) of various diseases.

Syndrome Symptoms Cushing's

Excess glucocorticoids is manifested in the form of the following symptoms:

1.

Obesity, which is especially pronounced in the area of ​​the body, the limbs at the same thinned;face "lunate" in the supraclavicular areas are body pillows and so-called "back of the neck of the buffalo";

2.

skin thinned, there is redness of the face;there is a tendency to easy occurrence of bruises;

3.

The skin stretching bands are observed;

4.

marked thinning and atrophy of the muscles of the extremities;

5.

Edema due to congestive heart failure;

6.

Nervous disorders, which include depression, emotional instability and increased excitability.

Medical Syndrome Cushing's Syndrome

these disorders has been described by neurologist NM Cushing in 1924, and in 1932 - American neurosurgeon G. Cushing and was named after the authors - Cushing's syndrome.The disease is 5-10 times more common in women, beginning with puberty or after childbirth and abortion.The frequency of the disease Cushing's syndrome - 1 case per 1 million people.